Table 1.
Drosophila SO-interacting proteins and their putative Xenopus orthologues
| SO-interacting proteins1 | Protein Activity2 | Interaction Confidence Score1 | Putative Xenopus Orthologues3 (Xl = X. laevis; Xt = X. tropicalis) |
|---|---|---|---|
| Eyes absent | Transcription factor | 0.624 | Eya1 (gi:13591786, Xl) Eya2 (gi:134024326, Xt) Eya3 (gi:58702065, Xl) Eya4 (Xt genomic sequence ENSXETG00000000110 in Ensembl database) |
| CG15459 | Unknown, only expressed in testis and adult in fly | 0.430 | Identified only in Drosophila |
| CG6688 | Ubiquitin-dependent protein catabolism, PDZ domain | 0.421 | Identified only in Drosophila |
| CG9083 | Unknown | 0.415 | Novel Ensembl predication (Xt genomic sequence ENSXETT00000000661 in Ensembl database) |
| Groucho | Transcription factor | 0.415 | Grg4/Tle4 (gi:50925318, Xl) ESG1/Tle3 (gi:50414464, Xl) ESG2 (gi:2408194, Xl) Grg5/AES (gi:38174466, Xl) |
| CG17265 | RNA interference | 0.413 | Coiled coil domain protein ccd85c (gi:169642663, Xt; gi:66912014, Xl)4 |
| CG5466 | Cell growth, protein binding | 0.406 | Identified only in Drosophila |
| C15 | Transcription factor | 0.404 | Hox11 (gi:10185813, Xl) Hox11L2 (gi:10185811, Xl) |
| CG1218 | Zn finger protein, unknown | 0.403 | Similar to C4orf27 EST (gi:8579074 Xl) |
| Pif1B | PFTAIRE-interacting factor 1B, protein binding, unknown | 0.402 | Identified only in Drosophila |
| SOBP | SO Binding Protein, transcription factor | 0.394 | SOBP (gi:159155685, Xt) Zinc finger protein 198 (gi:49903401, Xl) Zinc finger protein LOC414497 (gi:80479434, Xl) |
| CG4807 (Abrupt) | Transcription factor, BTB domain for protein dimerization | 0.393 | Identified only in Drosophila |
| CG1135 | Forkhead associated domain, putative nuclear signaling domain | 0.389 | LOC100049093 (gi:126631279, Xl) |
| CG7878 | Deadbox RNA helicase | 0.386 | Ddx43 (gi:112419338, Xt; gi:118404345, Xt)5 |
| CG5665 | Lipoprotein lipase | 0.373 | Lipase member H(Xt genomic sequence ENSXETG00000005849 ENSEMBL database) Phospholipase A1 member A (Xt genomic sequence ENSXETG00000018070 ENSEMBL database) |
| CG33090 | Hydroxymethylglutaryl-CoA reductase class I/II, bile acid glucosidase | 0.356 | GBA2 (gi: 169642398 Xt) |
| RhoGEF2 | Rho guanine nucleotide exchange factor | 0.331 | Guanine nucleotide exchange factor (gi:148223172, Xl) |
| Chc | Clathrin heavy chain, vesicle mediated transport | 0.330 | MCG80936 (gi:49115531, Xl) |
| CKIIβ | Casein kinase II regulatory subunit, role in Wnt signaling | 0.327 | Casein kinase II β subunit (gi:50414548, Xl) |
| CG10576 | Methionyl aminopeptidase activity; proteolysis | 0.325 | Proliferation-associated 2G4 (gi:54311186, Xl) |
| VhaAC39 | Proton transport, ATPase | 0.322 | ATPase Proton transporting lysosomal 38kD VO subunit d1 (gi:27769219, Xl) |
| RhoGAP93B | Rho GTPase activator protein | 0.312 | RhoGAP93B (Xt genomic sequence ENSXETG00000007422 Ensembl database) |
| CG5033 | Ribonucleoprotein binding, transcription factor | 0.294 | Hypothetical MGC68939 (gi:33416659, Xl) Block of proliferation (gi:2877251, Xl) |
| Gadd45 | Cell cycle regulator | 0.254 | gadd45α (gi:27694852, Xl) gadd45γ (gi:148223518, Xl) gadd45β (Xt genomic sequence ENSXETT00000008029 ENSEMBL database) |
| RpS27 | Cytosolic small ribosomal subunit | 0.202 | RpS27 (gi:297124, Xl) |
1
DroID, The Drosophila Interactions Database, Version 5.0, http://www.droidb.org/Index.jsp
2
Flybase, FB2010_04, http://flybase.org
3
If the X. laevis gene was identified in the BLAST search, the X. tropicalis gene is not listed (except for CG17265, see note 4).
4
Both X. laevis and X. tropicalis genes are listed for CG17265 (ccd85c) because the X. tropicalis gene has a higher amino acid sequence identity to CG17265 over its entire coding region.
5
These two NCBI GenBank entries for Ddx43 are identical in sequence, and thus are counted as only one gene in the text.