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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Ann Med. 2010 Nov 1;42(8):576–586. doi: 10.3109/07853890.2010.532811

Figure 1. Correlation between Power Density, Behavioral Improvement and Cortical ATP.

Figure 1

Panel A provides data for a correlation between Energy Density and Cortical ATP content measured following embolic strokes. The curve is biphasic showing a steep slope up to 4.5 J/cm2, and a shallow slope thereafter. As extrapolated value of 2.86 J/cm2 was calculated for “normalization” of ATP content to 100% of control(37); Panel B shows the correlation between Energy density and Behavioral Improvement. The data shows that a threshold Energy Density above equal to or above 0.9 J/cm2 is required to produce a significant (*p<0.05) increase in P50 values (Clot dose or burden in brain measured in mg that produces abnormality in 50% of the population) following an embolic stroke (24, 46).