Table I.
Genes Differentially Regulated in Sprouting Neurons at Day 7 in Young Adult
| Axonal Outgrowth/Guidance |
| Neuropilin 1 |
| Neuropilin and toll-like 2 (Neto2) |
| DEK oncogene |
| tyrosine ligase-like family, member 7 |
| Reticulon 4 receptor-like 1/NgR3 (down) |
| COUP-TFI/NR2F1 (down) |
| L1CAM (down) |
| Calcium signaling/homeostasis |
| Stromal interaction molecule 2 |
| Neurocalcin delta |
| Calmodulin 3 |
| Calreticulin |
| Calpactin |
| Intracellular phosphorylation cascades |
| Protein tyrosine phosphatase, non-receptor type 11 |
| Protein tyrosine phosphatase, receptor type, D (Ptprd) |
| Protein tyrosine phosphatase, receptor type, E (Ptpre) |
| Protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a), |
| PLCXD3 |
| Dual specificity protein phosphatase 3 |
| Serine/threonine protein phosphatase PP1-beta |
| MAP-kinase activating death domain |
| Phosphatase and tensin homolog |
| JNK2 |
| MAPK9 |
| Protein tyrosine phosphatase, non-receptor type 1 (Ptpn1) (down) |
| Inositol 1,4,5-triphosphate receptor 1 (Itpr1) (down) |
| Dual specificity phosphatase 5 (Dusp5) (down) |
| Protein tyrosine phosphatase 2E (Ptpn21) (down) |
| Cell Surface Receptors |
| CD164 |
| integrin alpha-6 |
| UDP-glucose ceramide glucosyltransferase |
| Tetraspanin 5 |
| SNX6 sorting nexin 6 |
| CD47 |
| Cadherin 2 (N-cadherin) |
| Protocadherin 7,9,19 (19 down) |
| Extracellular matrix |
| Osteopontin |
| Laminin-5beta3 |
| Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| Heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| Matrilin 2 |
| Growth Factors |
| Lip1 |
| BCATc |
| Platelet derived growth factor, alpha |
| Fgf13 (down) |
| Bex1 (down) |
| LIM motif-containing protein kinase 2 (Limk2) (down) |
| Insulin-like growth factor binding protein 5 (down) |
| GTPases/G protein coupled receptors |
| Rabaptin 5 |
| Rab2 |
| RanBP1 |
| RAB6a |
| Ras homolog gene family, member E (Arhe) |
| Rab12 |
| Rab26 |
| Rab22a |
| Afadin |
| Rhoa |
| Rab11a |
| Rab7a |
| Gpr83 (down) |
| Septin 5 (down) |
| Rab9b (down) |
| Ras homolog enriched in brain like 1 Rhebl1 (down) |
| RGS4 (down) |
| Latrophilin 3 (down) |
| GTPase activating protein testicular GAP1 (down) |
| T-cell lymphoma invasion and metastasis 2 (Tiam2) (down) |
| Connector enhancer of kinase suppressor of Ras 2 (down) |
| G protein-coupled receptor 22 (down) |
| Rho family GTPase 1 (Rnd1) (down) |
| RAS, dexamethasone-induced 1 (Rasd1) (down) |
| Gpr149 G protein-coupled receptor 149 (down) |
| Guanylate cyclase 1, soluble, alpha 3 (down) |
| MCH1/immune/complement |
| C1nh/Serping 1 |
| Complement C3 |
| CD46 |
| RT1 class Ib, locus Cl (RT1-Cl) (MHCI) |
| RT1 class Ib, locus S3 (RT1-S3) (MHCI) |
| RT1 class I, CE4 (RT1-CE4) (MHCI) |
| Adipsin/complement factor D |
| Complement receptor related protein (Crry) (down) |
| Ubiquitin/proteosome |
| Usp32 |
| Praja ring finger 2 PJA2 |
| HECT type E3 ubiquitin ligase (down) |
| SNF2 histone linker PHD RING helicase (down) |
| Ubiquitin-conjugating enzyme E2 Harrier protein (down) |
| Cytoskeletal protein or trafficking/migration |
| APC |
| Adducing 3 gamma |
| Kif1a |
| Actin, gamma 2 |
| SFRS protein kinase 2 |
| Stathmin 3/SCLIP |
| Stathmin 4/RB3 |
| Protein kinase A anchoring protein 11 |
| calsyntenin 1 |
| A kinase anchor protein 13 |
| Tumor protein, translationally-controlled 1 |
| Kelch domain containing 3 (Klhdc3) |
| Olfactomedin 3/Optimedin |
| Peroxiredoxin 1 |
| Destrin |
| Doublecortin-like kinase 1 |
| Doublecortin and calcium/calmodulin-dependent protein kinase-like 1 |
| Cyclin-dependent kinase inhibitor 1B |
| Kinesin family member 5B |
| Microtubulue associated protein 4 |
| Actin related protein 2/3 complex, subunit 4 |
| Desmoglein 1 gamma |
| Actin-related protein 3 (down) |
| Retinitis pigmentosa 2 (down) |
| Kinesin-like 7 |
| Kelch-like 23 (down) |
| Transcription factors |
| Bcl11b/Ctip2 |
| Gro/TLE |
| Kruppel-like factor 7 |
| Nuclear receptor subfamily 4, group A, member 2 |
| Janus kinase 1 |
| Mesoderm development candidate 2 |
| Mesoderm induction early response 1 |
| TSC-22 |
| Recombining binding protein suppressor of hairless |
| Nuclear factor I/X (Nfix) |
| Id3 |
| Smad1 |
| Luc7l |
| Stat3 |
| Activating transcription factor 2 |
| Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
| MED10--mediator complex subunit 10 |
| LIM domain only 2 |
| Palmdelphin (down) |
| Smad 5 (down) |
| Egr 2 (down) |
| Neuron specific/related |
| Purkinje cell protein 4 |
| Snap 25a |
| mGluR3 |
| Ganglioside-induced differentiation-associated-protein 1 amyloid precursor protein |
| Synaptotagmin 12 |
| Neuronal regeneration related protein |
| Glutamate receptor, ionotropic, |
| AMPA1 (alpha 1) |
| Complexin 1, Complexin 2 |
| Receptor expression enhancing protein |
| Pantothenate kinase 1 |
| integral membrane protein 2B (Itm2b) vesicle-associated membrane protein, associated protein B and C |
| Neurexin II (down) |
| Neurobeachin (down) |
| adenylate cyclase activating polypeptide 1/PACAP (down) |
| cholinergic receptor, muscarinic 3 (down) |
| neuropeptide Y receptor Y5 (down) |
| synaptotagmin XVII (down) |
| Cytokines/Chemokines |
| CXCL10 |
| CXCL13 |
| TNFAIP2 tumor necrosis factor, alpha-induced protein 2 |
| TIGIRR-1 |
| CD40/Tnfrsf5, transforming growth factor, beta 3 TGFb3 (down) |
| TNF receptor superfamily, member 11b (osteoprotegerin) (down) |
| Epigenetic or DNA modifying |
| Hdac4 |
| Dre1 |
| Nucleolin |
| Replication factor C |
| Kin KIN17 |
| Cyclin G1 |
| REST corepressor 1 |
| NAP1L1 |
| Never in mitosis gene a-related kinase 1 |
| Nucleoporin 88 (down) |
| EP300 (down) |
All genes upregulated in sprouting neurons vs. non-sprouting neurons unless noted as (down).