TABLE 3.
In-Hospital Mortality and Morbidities in VLBW Infants with Down Syndrome (DS) Compared to Other VLBW Infants in the Neonatal Research Network Born 1994-2008
| Group |
||||
|---|---|---|---|---|
| Outcome, N (%) or Mean (SD)1 |
DS N=133 |
Non-DS Chromosomal Anomaly N=329 |
Other Birth Defect N=2126 |
No Birth Defect N=47744 |
| Survived | 82 (62) | 96 (29) | 1226 (58) | 38827 (81) |
| Died | 51 (38) | 233 (71)*** | 900 (42) | 8917 (19)*** |
| Died within 12 h | 12 (9) | 77 (23)*** | 349 (16)* | 3414 (7) |
|
| ||||
| Infants who survived > 12 h | N=121 | N=252 | N=1777 | N=44330 |
| PDA | 70 (58) | 146 (58) | 878 (50) | 14154 (32)*** |
| NEC | 19 (16) | 10 (4)*** | 159 (9)* | 3409 (8)*** |
| Infants who survived > 12 h with CHD |
N=38 | N=77 | N=799 | -- |
| PDA | 22 (58) | 53 (69) | 457 (57) | -- |
| NEC | 9 (24) | 3 (4)** | 83 (10)* | -- |
| Infants who survived > 12 h without CHD |
N=83 | N=175 | N=978 | N=44330 |
| PDA | 48 (58) | 93 (53) | 421 (43)** | 14154 (32)*** |
| NEC | 10 (12) | 7 (4)* | 76 (8) | 3409 (8) |
|
| ||||
| Infants who survived > 3 d | N=120 | N=209 | N=1639 | N=42942 |
| Late-onset sepsis | 32 (27) | 29 (14)** | 488 (30) | 10237 (24) |
|
| ||||
| Infants who had a cranial | N=107 | N=207 | N=1603 | N=41324 |
| sonogram within 28 days2 | ||||
| Severe IVH | 14 (13) | 15 (7) | 210 (13) | 4878 (12) |
| Infants who had a late cranial sonogram3 |
N=99 | N=178 | N=1444 | N=38450 |
| PVL | 4 (4) | 6 (3) | 87 (6) | 1618 (4) |
| Infants with sufficient information to include in analysis 4 |
N=96 | N=180 | N=1440 | N=38449 |
| Severe IVH or PVL | 14 (15) | 20 (11) | 255 (18) | 5630 (15) |
|
| ||||
| Infants still in the hospital at 28 days who had an ROP examination |
N=74 | N=82 | N=1112 | N=30019 |
| ROP5 | 22 (30) | 27 (33) | 535 (48)** | 14358 (48)** |
| ROP stage 3 or higher5 | 1 (1) | 5 (6) | 119 (11)** | 3400 (11)** |
|
| ||||
| Infants alive at 36 weeks PMA | N=94 | N=109 | N=1273 | N=37816 |
| BPD6 | 36 (38) | 55 (50) | 562 (44) | 10482 (28)* |
|
| ||||
| Infants with growth measurements at 36 w PMA, Mean (SD)7 |
N=84 | N=123 | N=1139 | N=30620 |
| Weight (g) | 1783 (482) | 1497 (389)*** | 1784 (431) | 1937 (390)*** |
| Length (cm) | 41.1 (2.9) | 39.7 (3.3)** | 41.3 (3.2) | 42.4 (2.9)*** |
| Head circumference (cm) | 29.5 (1.8) | 29.3 (2.3) | 30.2 (2.1)*** | 30.9 (1.7)*** |
SD= standard deviation; PDA=patent ductus arteriosus; NEC=necrotizing enterocolitis; CHD=congenital heart defect; IVH=intraventricular hemorrhage; PVL=periventricular leukomalacia; ROP=retinopathy of prematurity; BPD=bronchopulmonary dysplasia. Information was missing for PDA: 29 infants; NEC: 19; late-onset sepsis: 44.
Severe IVH was defined as grade 3 or 4. Excludes 37 infants with missing results.
PVL based, for infants born before August 1998, on sonogram findings at 2 weeks or greater and, for infants born after August 1998, on sonogram findings within 28 days or closest to 36 weeks PMA and after 28 days. Excludes 26 infants with missing results.
Percents were based on infants with non-missing IVH and PVL outcomes, except that a diagnosis of either condition was sufficient to set the outcome to yes. Excludes 3403 infants with missing results.
Information was missing for ROP: 6 infants; ROP stage 3 or higher: 27 infants.
BPD was defined as supplemental oxygen use at 36 weeks PMA. Excludes 1548 infants with missing information and 239 infants born at 36 weeks GA or later.
Numbers (Ns) shown are infants who have at least one 36-week measurement. In this group of infants, information was missing for weight: 38 infants; length: 3550, head circumference: 1505.
p ≤ 0.05
p ≤ 0.01
p ≤ 0.001 for a test between infants with DS versus each of the other groups by the t-test (means for weight, length, head circumference) or the chi-square test.