Table 3. fMRI activations Talairach coordinates and corresponding z-scores.
| z-Score | x | y | z | Left/right | Region | Brodmann area |
|---|---|---|---|---|---|---|
| BASELINE GROUPS ANALYSIS | ||||||
| Healthy controls n = 9 | ||||||
| RMET group mean | ||||||
| 5.7 | −46 | 14 | 26 | Left | Middle frontal gyrus | Brodmann area 9 |
| 5.57 | 22 | −64 | 54 | Right | Superior parietal lobule | Brodmann area 7 |
| 5.51 | −6 | 6 | 60 | Left | Superior frontal gyrus | Brodmann area 6 |
| 5.4 | 32 | −62 | 52 | Right | Superior parietal lobule | Brodmann area 7 |
| 5.19 | −20 | −64 | 58 | Left | Superior parietal lobule | Brodmann area 7 |
| 4.87 | −32 | −84 | −10 | Left | Inferior occipital gyrus | Brodmann area 18 |
| RMET minus gender group mean | ||||||
| 4.5 | −10 | 26 | 56 | Left | Superior frontal gyrus | Brodmann area 6 |
| 4.39 | −10 | 12 | 6 | Left | Caudate | Caudate Body |
| 4.32 | −6 | 54 | 40 | Left | Medial frontal gyrus | Brodmann area 9 |
| 3.99 | −12 | 50 | 28 | Left | Superior frontal gyrus | Brodmann area 9 |
| 3.91 | −10 | 58 | 22 | Left | Superior frontal gyrus | Brodmann area 10 |
| 3.85 | 56 | −40 | −4 | Right | Middle temporal gyrus | Brodmann area 21 |
| 5.79 | −46 | 26 | −10 | Left | Inferior frontal gyrus | Brodmann area 47 |
| 5.21 | −54 | 22 | 8 | Left | Inferior frontal gyrus | Brodmann area 45 |
| 4.52 | −52 | −48 | 2 | Left | Middle temporal gyrus | Brodmann area 22 |
| 3.79 | −42 | 10 | −36 | Left | Middle temporal gyrus | Brodmann area 21 |
| Unmedicated depressed n = 8 | ||||||
| RMET group mean | ||||||
| 5.29 | 10 | 18 | 40 | Right | Cingulate gyrus | Brodmann area 32 |
| 4.83 | 36 | 22 | 0 | Right | Insula | Brodmann area 13 |
| 4.66 | −22 | −58 | 44 | Left | Superior parietal lobule | Brodmann area 7 |
| 4.55 | 30 | −4 | 50 | Right | Middle frontal gyrus | Brodmann area 6 |
| 4.35 | −10 | 8 | 2 | Left | Caudate | Caudate Head |
| RMET minus gender group mean | ||||||
| 4.3 | −58 | 22 | 4 | Left | Inferior frontal gyrus | Brodmann area 45 |
| 4.14 | −48 | 14 | −161 | Left | Superior temporal gyrus | Brodmann area 38 |
| 4.11 | −40 | 28 | −10 | Left | Inferior frontal gyrus | Brodmann area 47 |
| 4.04 | −10 | 14 | −6 | Left | Caudate | Caudate head |
| 2.3 | −14 | 10 | −22 | Left | Anterior cingulate gyrus | Brodmann area 25 |
| DIRECT COMPARISONS BETWEEN INTRA-NASAL OXYTOCIN AND PLACEBO | ||||||
| Healthy matched controls n = 9 | ||||||
| RMET healthy oxytocin > placebo t-test | ||||||
| 3.93 | −6 | 6 | −8 | Left | Caudate | Caudate head |
| 3.82 | 12 | −4 | −20 | Right | Parahippocampal gyrus | Brodmann area 34 |
| 2.66 | 14 | −2 | −22 | Right | Amygdala | |
| 3.73 | 28 | 32 | −18 | Right | Inferior frontal gyrus | Brodmann area 47 |
| 3.72 | −8 | 0 | −6 | Left | Lentiform nucleus | * |
| 3.67 | −10 | 32 | −6 | Left | Anterior cingulate | Brodmann area 24 |
| 3.67 | 30 | −24 | −24 | Right | Parahippocampal gyrus | Brodmann area 35 |
| 4.24 | −40 | −30 | −10 | Left | Caudate | Caudate tail |
| 3.94 | −50 | 8 | −18 | Left | Superior temporal gyrus | Brodmann area 38 |
| 3.7 | −56 | −8 | −6 | Left | Superior temporal gyrus | Brodmann area 22 |
| 2.7 | −4 | 18 | −12 | Left | Anterior cingulate gyrus | Brodmann area 25 |
| 2.69 | −4 | 48 | −14 | Left | Anterior cingulate gyrus | Brodmann area 32 |
| Gender healthy oxytocin > placebo t-test | ||||||
| No significant differences | ||||||
| Motor healthy oxytocin > placebo t-test | ||||||
| 3.99 | 50 | −27 | 10 | Right | Superior temporal gyrus | Brodmann area 41 |
| 3.76 | 16 | −30 | 11 | Right cerebellum | ||
| 3.72 | 60 | −21 | 9 | Right | Superior temporal gyrus | Brodmann area 42 |
| 3.65 | 47 | −31 | 15 | Right | Superior temporal gyrus | Brodmann area 41 |
| 3.62 | 51 | −23 | 10 | Right | Transverse temporal gyrus | Brodmann area 41 |
| 3.62 | 51 | −30 | 15 | Right | Superior temporal gyrus | Brodmann area 41 |
| Depressed unmedicated n = 8 | ||||||
| RMET depressed oxytocin > placebo t-test | ||||||
| 3.99 | 58 | 10 | −20 | Right | Superior temporal gyrus | Brodmann area 38 |
| 3.79 | 54 | 8 | 2 | Right | Insula | Brodmann area 13 |
| 3.77 | 56 | 12 | 6 | Right | Precentral gyrus | Brodmann area 44 |
| 3.73 | 50 | 18 | −14 | Right | Inferior frontal gyrus | Brodmann area 47 |
| 3.71 | 58 | 8 | −10 | Right | Superior temporal gyrus | Brodmann area 22 |
| 3.76 | −4 | 36 | 16 | Left | Anterior cingulate | Brodmann area 24 |
| 3.75 | 6 | 34 | 26 | Right | Cingulate gyrus | Brodmann area 32 |
| 3.72 | −4 | 36 | 20 | Left | Anterior cingulate | Brodmann area 32 |
| 3.7 | 6 | 38 | 30 | Right | Medial frontal gyrus | Brodmann area 6 |
| 3.73 | −56 | −30 | 10 | Left | Superior temporal gyrus | Brodmann area 41 |
| 3.73 | −64 | −52 | 24 | Left | Superior temporal gyrus | Brodmann area 22 |
| 3.69 | −58 | −48 | 32 | Left | Supramarginal gyrus | Brodmann area 40 |
| 3.65 | −52 | −32 | 8 | Left | Superior temporal gyrus | Brodmann area 22 |
| 3.54 | 30 | 58 | −6 | Right | Superior frontal gyrus | Brodmann area 10 |
| 3.52 | 44 | 36 | 28 | Right | Middle frontal gyrus | Brodmann area 9 |
| 3.41 | 28 | 44 | 34 | Right | Middle frontal gyrus | Brodmann area 8 |
| 3.35 | 34 | 52 | 12 | Right | Middle frontal gyrus | Brodmann area 10 |
| 3.33 | 24 | 48 | 22 | Right | Superior frontal gyrus | Brodmann area 9 |
| RMET minus gender depressed oxytocin > placebo t-test | ||||||
| No significant differences | ||||||
| Gender depressed oxytocin > placebo t-test | ||||||
| No significant differences | ||||||
| Motor depressed oxytocin > placebo t-test | ||||||
| 3.51 | 0 | 58 | 28 | Left | Medial frontal gyrus | Brodmann area 9 |
| 3.41 | −18 | 56 | 30 | Left | Superior frontal gyrus | Brodmann area 9 |
| 3.39 | 4 | 60 | 34 | Right | Medial frontal gyrus | Brodmann area 8 |
| 3.44 | −2 | 58 | 38 | Left | Medial frontal gyrus | Brodmann area 8 |
| 3.47 | 2 | 56 | 32 | Left | Medial frontal gyrus | Brodmann area 6 |
| 3.59 | −2 | 34 | 54 | Left | Superior frontal gyrus | Brodmann area 6 |
| 3.6 | 8 | 6 | 56 | Right | Medial frontal gyrus | Brodmann area 6 |