Table 3.

The domains of ‘manic-like’ behavior modeled in the battery, the expected response and actual response to mood stabilizers in BS mice.

Test	Domain of manic-like behavior	Expected response to mood stabilizers	Actual response to lithium	Actual response to valproate
Sweet solution preference	Reward seeking behavior	Reduction in preference	Reduction in preference	Reduction in preference
Forced swim test	Resistance to despair/increased vigor	Increase in immobility	No effect	Increase in immobility
Resident-intruder test	Aggression	Reduced aggression	No effect	No effect
Dark/light box	Risk taking behavior	Reduced time in light Compartment	No effect	No effect
Amphetamine-induced hyperactivity	Manic-like increased activity or sensitivity to psychostimulants	Reduced hyperactivity	Reduced hyperactivity	Reduced hyperactivity (strong trend)