Table 2.

Synaptic proteins that are processed by MMPs.

Substrate	Protease	Relevance to synaptic structure/function	Reference(s)
N-cadherin	MT5-MMP MMP-7 ADAM-10	Synapse formation and plasticity	Williams et al. (2010), Monea et al. (2006), Kohutek et al. (2009)
Telencephalin/ICAM-5	MMP-2, -3, -7, -9	Shedding is associated with changes in dendritic spine morphology and may play a role in select forms of plasticity	Conant et al. (2010), Tian et al. (2007)
NR1	MMP-3 MMP-7	Obligate subunit of the NMDA type glutamate receptor	Pauly et al. (2008), Szklarczyk et al. (2008)
NR2A	MMP-7	Subunit of the NMDA type glutamate receptor	Szklarczyk et al. (2008)
Neuronal pentraxin receptor (NPR)	ADAM-17	Ectodomain shedding allows an N terminal fragment to surround and internalize AMPA type glutamate receptors, thus contributing to synaptic plasticity/long term depression	Cho et al. (2008)
SNAP-25	MMP-7	Synaptic vesicle/neurotransmitter release	Szklarczyk et al. (2007b)
Pro-BDNF	MMP-3 MMP-7	Effector of neuronal survival and synaptic plasticity	Lee et al. (2001)
IGFBP-6	MMP-9 MMP-12	IGFBP-6 may sequester IGF, a potent effector of neuronal survival and a potential contributor to synapse formation	Larsen et al. (2006)
Brevican	MMP-9	Structural stability of the synapse. Proteolytic cleavage has been associated with synaptic loss	Yuan et al. (2002)
Laminin-γ2	MT1-MMP	Structural stability of the synapse	Koshikawa et al. (2005)