Figure 2.
Chemical transmission between striatal neurons. (A) Fast-spiking GABAergic interneurons have a strong inhibitory weight on MSNs: an action potential in the interneuron evokes an IPSC in the MSN (Adapted from Tepper et al., 2004). (B) Dual patch-clamp recording illustrating the inhibitory action of nNOS interneurons on MSNs (Adapted from Tepper and Bolam, 2004) (C) Illustration of the excitatory effect of cholinergic interneurons on MSNs: an extracellularly evoked action potential in a cholinergic interneuron evokes an EPSC in the MSNs (Adapted from Lin et al., 2004).