. 2010 Aug 6;2:28. doi: 10.3389/fnsyn.2010.00028

Table 1.

Types of MeCP2 mouse mutants tested for defects in synaptic connectivity and plasticity.

Mouse model	Mutation type	Mutation result	Mutant life span
MeCP2^Jae (Chen et al., 2001)	Deletion of exon 3 (homologous recombination)	Loss of function	Male^y/−: 10–12 weeks; Female^+/−: normal
MeCP2^Bird (Guy et al., 2001)	Deletion of exons 2 and 3 (homologous recombination)	Loss of function	Male^y/−: 7–8 weeks; Female^+/−: normal
MeCP2³⁰⁸ (Shahbazian et al., 2002)	Stop codon after 308 codon (homologous recombination)	Truncated MeCP2 protein	Male^y/308: 10% about 10 months; 90% at least 1 year
MeCP2^Tg1 (Collins et al., 2004)	Insertion of PAC clone containing MeCP2 under endogenous human promoter	MeCP2 overexpression	Male: 30% between 20 weeks to 1 year; 70% normal