Table 3.
Synaptic effects of pharmacological and behavioral treatments in MeCP2 mutant mice.
| Intervention Synaptic parameter | Genetic reactivation of MeCP2 (Guy et al., 2007) | CAGGsBDNF;Mecp2KO (Chang et al., 2006) | EE (Lonetti et al., 2010) | IGF1 treatment (Tropea et al., 2009) |
|---|---|---|---|---|
| Excitatory synaptic density | ? | ? | + | + |
| Inhibitory synaptic density | ? | ? | − | ? |
| Synaptic currents | ? | +* | ? | +** |
| Synaptic plasticity | + | ? | + | +*** |
Synaptic effects induced by genetic reactivation of MeCP2, genetic overexpression of BDNF, environmental enrichment (EE), and pharmacological treatments with IGF1 are indicated. See text for details.
? Not tested, + affected by the intervention, − not affected.
* Only firing rate of cortical layer V pyramidal neurons **only excitatory spontaneous EPSCs in the layer V of the cortex*** tested using ocular dominance plasticity.