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. 2010 Jul 1;2:15. doi: 10.3389/fnsyn.2010.00015

Figure 3.

Figure 3

Antagonism of adenosine A1 receptors does not affect reduction of EPSC amplitude by pH6 aCSF. (A) The reduction of EPSC amplitude was not affected by antagonism of adenosine A1 receptors. Baseline EPSC amplitude was determined in the presence of the A1 receptor antagonist 8-CPT (10 μM). The slice was superfused with pH6 aCSF containing 8-CPT (10 μM) 5 min after cessation of stimulation. Resumption of stimulation after 15 min produced an inhibition of the EPSC amplitude, comparable with that observed in the absence of 8-CPT. Representative EPSCs show the final baseline response (i) and the first response evoked in pH6 solution containing 8-CPT (10 μM) (ii). (B) As seen in the absence of 8-CPT, the EPSC amplitude was augmented after stimulation in pH7.4 containing 8-CPT (10 μM). Traces show the final baseline response (i) and the first response evoked in pH7.4 containing 8-CPT (10 μM) (ii).