Figure 8.

FCCP does not immediately affect the amplitude of the GABA_A-mediated IPSC. (A) Diary plot of IPSC amplitude showing that the initial mean IPSC after resumption of stimulation was unaffected by the application of FCCP (3 μM). Representative individual IPSCs from a single experiment show the final baseline response (i) and the first response evoked in FCCP (ii). The subsequent decline in IPSC amplitude upon stimulation is comparable with that seen under control conditions. (B) The diary plot shows that application of the vehicle control (0.03% ethanol) had no initial effect on the mean IPSC amplitude, with the mean IPSC amplitude gradually decreasing over the next 15 min of recording. Representative individual IPSCs from a single experiment show the final baseline response (i) and the first response evoked in ethanol (0.03%) (ii).