Figure 5.

Parallel induction of e-LTP/i-LTP and e-LTD/i-LTD occurs under prominent postsynaptic GABA_AR-mediated inhibition. (A) Normalized EPSC/FF-IPSC amplitudes (%) without the spike-timing protocol. No changes in either EPSCs or FF-IPSCs were observed during the time course of the experiments. (B,C) EPSCs and FF-IPSCs were both potentiated at the LTP time intervals (B), and depressed at the –LTD time intervals (C). (D) DSI abolished LTD of EPSC, but not of FF-IPSC at the –LTD time intervals. Data represent normalized mean EPSCs/FF-IPSCs (±sem). Sample traces of EPSCs/FF-IPSCs (in B–D) before (1) and after (2) the induction protocols. Significant differences from corresponding controls are indicated (“*” p < 0.05 and “**” p < 0.01; Mann–Whitney U test).