Figure 2.

Short-term frequency-dependent facilitation of MF-GPSCs. (A) Upper trace: MF-GPSCs exhibiting strong paired-pulse facilitation in response to two stimuli (50 ms apart) delivered to the granule cells in the dentate gyrus (P3). Lower traces represent averaged responses (including failures) obtained at 0.05 and 0.33 Hz from the same neuron. (B) The mean amplitude of synaptic currents evoked in 6 pyramidal cells at 0.05 and 0.33 Hz (bars) is plotted against time. Note the slow build-up of facilitation of synaptic responses at 0.33 Hz that completely reversed to control values after returning to 0.05-Hz stimulation. Bars represent SEM. (C,D) as in (A,B) but for neurons recorded at P5–P6. (C,D) modified from Safiulina et al., 2006.