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. 2011 Mar 16;100(6):1517–1525. doi: 10.1016/j.bpj.2011.01.068

Figure 2.

Figure 2

DSC thermograms for the thermal denaturation of the c-MYC WT P1 promoter 24-mer G-quadruplex in (a) 30 mM [K+] and (b) 130 mM [K+] BPES. In the lower ionic strength solution, the raw excess heat capacity has been deconvoluted into two “two-state processes.” The lower melting transition is attributed to the 1-6-1 isomer with a Tm of 72.4°C, and the higher melting conformer is attributed to the 1-2-1 isomer (Tm of 80.6°C). The raw excess heat capacity has been deconvoluted into two “two-state processes.” The lower melting conformer is attributed to the 1-6-1 isomer (Tm of 78.8°C), and the higher melting conformer is attributed to the 1-2-1 isomer (Tm of 93.1°C).