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. Author manuscript; available in PMC: 2011 Mar 17.
Published in final edited form as: J Am Chem Soc. 2010 Jun 16;132(23):8010–8019. doi: 10.1021/ja1003922

Figure 4.

Figure 4

Comparison of conventional triple mutant cube (A) vs. semi-mutant cube (B). In the semi-mutant cube, a double mutant cycle (V34L/P58Y) forms the base of the cube, and the equilibrium between open and closed states (measured via HX) at another position (shown here as Y29) is shown as vertical transitions. Notations and color-coding are as in Figure 1.