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. Author manuscript; available in PMC: 2011 Mar 17.
Published in final edited form as: J Am Chem Soc. 2010 Jun 16;132(23):8010–8019. doi: 10.1021/ja1003922

Figure 7.

Figure 7

Overlap of perturbation spheres giving rise to 3rd-order couplings. In given protein (gray), mutations at site A and B (green) induce spheres of perturbation shown in blue and red, respectively. Residues C, D, and E report SSO 3rd-order couplings (decreasing such that C > D > E, shading scheme as in Figure 6) together with with A and B.