Table 2.
Acetaminophen pharmacokinetic data calculated from saliva samples (reported as median, range values)
| Control | NAFLD | |
|---|---|---|
| Cmax 1 (mg/L) | 10.1 (3.23–24.7) | 10.0 (5.46–49.45) |
| Elimination rate constant kel (h−1) | 0.198 (0.071–0.310) | 0.236 (0.130–0.406) |
| Elimination half life (h) | 3.52 (2.236–9.763) | 2.94 (1.707–5.332) |
| AUC 2 (mg/h·L) | 10.2 (5.89–23.0) | 12.6 (6.58–28.2) |
| Clearance (L/kg·h) | 0.31 (0.15–0.53) | 0.31 (0.11–0.59) |
1
Cmax: peak concentration after drug administration
2
AUC: area under the curve