Fig. 1.

S. oneidensis and S. frigidimarina viability after exposure to HSP90 specific inhibitor 17AGG. a Dose–response experiments of 17AGG in S. oneidensis cultures at 12°C. Values are given in absorbances (test 595 nm, reference 690 nm). The calculated IC50 was 7.7 μM. 17AGG decreased MTT activity in S. oneidensis (b) and S. frigidimarina (c) at 12°C and 30°C. Data represent the mean ± SEM of three experiments run in duplicate. Statistical differences were studied by Student’s t test (*p < 0.05; **p < 0.01; ***p < 0.001, compared to the corresponding control). d MTT activity in cultures of S. oneidensis and S. frigidimarina treated with 17AGG. Statistical differences were studied by one-sample t test (*p < 0.05; **p < 0.01; ***p < 0.001), compared to the corresponding control as 100%, and comparison between percentages were done by Student’s t test