Table 1.
Baseline characteristics, overall and by VTE status.
| VTE status |
|||
|---|---|---|---|
| Characteristic | Overall (n = 26,450) | No VTE (n = 25,942) | VTE (n = 508) |
| Age (years) | 63.4 ± 7.2 | 63.4 ± 7.2 | 66.1 ± 6.6 |
| Race/ethnicity | |||
| Non-Hispanic white | 21,609 (81.7) | 21,166 (81.6) | 443 (87.2) |
| Non-Hispanic black | 2,699 (10.2) | 2,646 (10.2) | 53 (10.4) |
| Hispanic | 1,498 (5.7) | 1,491 (5.7) | 7 (1.4) |
| Other | 644 (2.4) | 639 (2.5) | 5 (1.0) |
| Education | |||
| Some high school | 2,130 (8.0) | 2,085 (8.0) | 45 (8.9) |
| High school graduate | 5,454 (20.6) | 5,348 (20.6) | 106 (20.9) |
| Some college | 10,733 (40.6) | 10,531 (40.6) | 202 (39.7) |
| ≥ College degree | 8,133 (30.8) | 7,978 (30.8) | 155 (30.5) |
| BMI (kg/m2) | 29.1 ± 6.0 | 29.1 ± 6.0 | 31.2 ± 6.6 |
| Coronary heart disease | 494 (1.9) | 484 (1.9) | 10 (2.0) |
| Peripheral arterial disease | 440 (1.7) | 429 (1.7) | 11 (2.2) |
| Stroke | 294 (1.1) | 285 (1.1) | 9 (1.8) |
| Hypercholesterolemia | 3,206 (12.1) | 3,146 (12.1) | 60 (11.8) |
| Cancer | 840 (3.2) | 817 (3.1) | 23 (4.5) |
| Fracturea | 211 (0.8) | 206 (0.8) | 5 (1.0) |
| Aspirin or NSAID use | 10,150 (38.4) | 9,906 (38.2) | 244 (48.0) |
| Current smoking | 2,735 (10.5) | 2,693 (10.5) | 50 (8.4) |
| Physical activity (kcal/kg/week) | 10.0 ± 11.2 | 10.0 ± 11.2 | 8.7 ± 10.6 |
| Randomization status | |||
| E | 5,104 (19.3) | 4,991 (19.2) | 113 (22.2) |
| Placebo for E arm | 5,228 (19.8) | 5,139 (19.8) | 89 (17.5) |
| E + P | 8,255 (31.2) | 8,064 (31.1) | 191 (37.6) |
| Placebo for E + P arm | 7,863 (29.7) | 7,748 (29.9) | 115 (22.6) |
| Daily temperature (°C) | NA | NA | 13.0 ± 9.5 |
| Season | |||
| January–March | NA | NA | 177 (34.8) |
| April–June | NA | NA | 124 (24.4) |
| July–September | NA | NA | 150 (29.5) |
| October–December | NA | NA | 57 (11.2) |
| Follow-up time (person-years) | 198,048 | 195,898 | 2,150 |
Abbreviations: E, CEE, 0.625 mg/day; E + P, CEE, 0.625 mg/day plus medroxyprogesterone acetate, 0.25 mg/day; NA, not applicable for participants without event. Data are reported as n (%) or mean ± SD. Descriptive data include imputed baseline covariate data.
a
Hip or femur.