Figure 5.

RDX reduced GABA-evoked currents in the BLA. Whole-cell recordings from principal neurons in the BLA were obtained in the presence of CNQX, AP-5, and SCH50911. (A) RDX (40 μM) reduced the outward postsynaptic current elicited by 500-msec pressure application of 200 μM GABA onto a pyramidal BLA neuron (V_h = +40 mV). (B) RDX (40 μM) reduced the inward postsynaptic current elicited by 500-msec pressure application of 200 μM GABA onto a pyramidal BLA neuron (V_h = −70 mV). In both A and B, each current trace is the average of four current recordings, and the black bar indicates the period of GABA application. After recording control current traces, RDX was applied to the bath; 4 min later, several GABA-evoked currents were recorded. Current amplitudes recovered partially after the washout of RDX. (C) Group data (mean ± SE; absolute current amplitude from both V_hold +40 mV and V_hold −70 mV experiments; n = 6) showing the effect of RDX on the amplitude of GABA-evoked currents.

^#p < 0.05.