Lack of ATP-dependent unwinding of Oris(GC)18
by UL9 protein-ICP8 complex. (a) Reaction mixtures for
helicase measurements were prepared as described in Materials
and Methods with 1 pmol OrisT18 or 1
pmol Oris(GC)18, and the indicated amounts of
UL9 protein and ICP8. ▵, OrisT18 and
Oris(GC)18, heated at 100°C for 5 min.
Incubation and PAGE were performed as described in Materials and
Methods. (b) Reaction mixtures for gel mobility
shift measurements were prepared as described in Materials and
Methods with 0.5 pmol Oris(GC)18 and
the indicated amounts of UL9 protein and ICP8. Samples were processed
as described in Materials and Methods. ds, double
stranded; ss, single stranded.