Table 2.
Regression coefficients between mean childhood blood lead and measured regional metabolite concentration levels in an unadjusted model and in a model adjusted for age at time of imaging and FSIQ, respectively.
| Unadjusted |
Age and FSIQ adjusted |
||||
|---|---|---|---|---|---|
| Voxel location | Metabolite | Beta | 95% CI | Beta | 95% CI |
| Basal ganglia (left) | NAA | −0.05 | −0.09 to −0.003 | −0.05 | −0.1 to −0.01* |
| Cr | −0.05 | −0.08 to −0.01 | −0.05 | −0.09 to −0.01* | |
| Cho | −0.01 | −0.02 to 0.001 | −0.01 | −0.02 to 0.002 | |
| GLX | −0.07 | −0.16 to 0.02 | −0.08 | −0.18 to 0.01 | |
| mI | 0.001 | −0.03 to 0.03 | 0.001 | −0.03 to 0.04 | |
| Cerebellar hemisphere (left) | NAA | −0.06 | −0.11 to −0.01 | −0.05 | −0.11 to −0.01* |
| Cr | −0.02 | −0.06 to 0.02 | −0.02 | −0.06 to 0.02 | |
| Cho | −0.01 | −0.03 to 0.00 | −0.01 | −0.03 to 0.00* | |
| GLX | −0.19 | 0.02 to 0.01 | −0.07 | −0.15 to 0.01 | |
| mI | −0.02 | −0.07 to 0.02 | −0.02 | −0.06 to 0.03 | |
| Cerebellar vermis (midline) | NAA | −0.02 | −0.05 to 0.01 | −0.01 | −0.04 to 0.01 |
| Cr | −0.02 | −0.05 to 0.01 | −0.01 | −0.04 to 0.01 | |
| Cho | −0.005 | −0.01 to 0.002 | −0.005 | −0.01 to 0.003 | |
| GLX | −0.06 | −0.11 to −0.01 | −0.07 | −0.12 to −0.02* | |
| mI | −0.001 | −0.03 to 0.03 | 0.01 | −0.02 to 0.04 | |
| Frontal gray matter (medial) | NAA | −0.02 | −0.04 to 0.01 | −0.02 | −0.04 to 0.01 |
| Cr | −0.01 | −0.03 to 0.01 | −0.01 | −0.03 to 0.01 | |
| Cho | −0.004 | 0.01 to 0.002 | −0.003 | −0.01 to 0.004 | |
| GLX | −0.03 | −0.08 to 0.02 | −0.02 | −0.08 to 0.03 | |
| mI | 0.02 | −0.01 to 0.04 | 0.02 | −0.01 to 0.04 | |
| Frontal white matter (left) | NAA | −0.02 | −0.05 to 0.01 | −0.02 | −0.05 to 0.02 |
| Cr | −0.004 | −0.03 to 0.02 | −0.004 | −0.03 to 0.02 | |
| Cho | −0.01 | −0.02 to −0.004 | −0.01 | −0.02 to −0.001* | |
| GLX | −0.08 | −0.15 to −0.004 | −0.06 | −0.14 to 0.01 | |
| mI | 0.003 | −0.02 to 0.03 | 0.004 | −0.03 to 0.03 | |
| Parietal white matter (left) | NAA | −0.02 | −0.05 to 0.004 | 0 | −0.04 to 0.01 |
| Cr | −0.01 | −0.03 to 0.003 | −0.01 | −0.02 to 0.01 | |
| Cho | −0.01 | −0.01 to −0.002 | −0.01 | −0.01 to −0.001* | |
| GLX | −0.05 | −0.09 to −0.01 | −0.05 | −0.09 to −0.01* | |
| mI | 0 | −0.03 to 0.02 | −0.001 | −0.02 to 0.02 | |
| Temporal lobe (STG-left) | NAA | −0.02 | −0.07 to 0.02 | −0.02 | −0.06 to 0.03 |
| Cr | −0.01 | −0.04 to 0.01 | −0.01 | −0.04 to 0.02 | |
| Cho | −0.01 | −0.01 to 0.002 | −0.01 | −0.01 to 0.002 | |
| GLX | −0.03 | −0.09 to 0.03 | −0.03 | −0.09 to 0.04 | |
| mI | −0.02 | −0.05 to 0.01 | −0.01 | −0.04 to 0.02 | |
*
p < 0.05.