Table 2.
Subgroup | Genotype | Controls | Cases | OR a (95%CI) | P-value |
---|---|---|---|---|---|
Age ≤ 50 | GG | 461 | 121 | 1 | |
GA/AA | 183/31 | 66/9 | 1.34 (0.96–1.86) | 0.09 | |
Age > 50 | GG | 461 | 283 | 1 | |
GA/AA | 183/31 | 173/28 | 1.53 (1.20–1.95) | 0.0006 | |
Family history negative |
GG | 461 | 316 | 1 | |
GA/AA | 183/31 | 188/28 | 1.47 (1.16–1.87) | 0.001 | |
Family history positive |
GG | 461 | 88 | 1 | |
GA/AA | 183/31 | 51/9 | 1.47 (1.02–2.12) | 0.04 | |
BRCA mutation | GG | 461 | 48 | 1 | |
GA/AA | 183/31 | 25/6 | 1.39 (0.86–2.25) | 0.18 | |
No BRCA mutation |
GG | 461 | 322 | 1 | |
GA/AA | 183/31 | 196/29 | 1.51 (1.19–1.90) | 0.0007 |
All cases and controls in this table were from ethnic group “Other White”.