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. Author manuscript; available in PMC: 2011 Mar 17.
Published in final edited form as: J Pharmacol Exp Ther. 1984 Nov;231(2):343–354.

Fig. 1.

Fig. 1

Dose-response relationships of L-dopa to induce SMB in adult and neonatal 6-OHDA-treated rats. A second dose of L-dopa (100 mg/ kg) was administered to 53 of the neonatal 6-OHDA-treated rats and to 18 of the adult-treated 6-OHDA-treated rats in table 1. After this determination, 6 neonatal 6-OHDA-treated rats that were negative at 100 mg/ kg of L-dopa and 10 of the adult 6-OHDA-treated rats were given 300 mg/kg of 6-OHDA. The neonatal 6-OHDA-treated rats positive for SMB at the 100 mg/kg dose were given 30 mg/kg of L-dopa. Those SMB positive rats at 30 mg/kg of L-dopa were subsequently given 10 mg/kg of L-dopa. Percent exhibiting SMB was determined from the initial group tested (53) at the 100 mg/kg dose of L-dopa. Log L-dopa dose indicates that doses are plotted on a logarithmic scale.