. Author manuscript; available in PMC: 2011 Mar 17.

Published in final edited form as: J Pharmacol Exp Ther. 1984 Nov;231(2):343–354.

TABLE 6. Effect of central dope decarboxylase inhibition, a dopamine-β-hydroxytase inhibitor, and neuroleptics on SMB induced by L-dopa.

Rats were treated with RO-4-4602 (50 mg/kg or higher doses) 60 min before injection of L-dopa (30 mg/kg). The oopamine-β-hydroxylase inhibitor, U-14,624, haloperidol and cisflupentixol were administered 45 min before administration of L-dopa.

Treatment	Dose	L-dope-induced Incidence of SMB (No./Total)
	(mg/kg)
Saline		18/18
RO-4-4602	500–800	7/7
U-14,624	50	6/6
Haloperidol	1	2/7^*
Flupentixol^a	1	0/6^*

Rats pretreated with cisflupentixol received 100 mg/kg of L-dopa rather than the 30 mg/kg received by the other rats.

P < .05 when compared to saline.