Table 1. Measured vascular volumes (V_v) in naïve and anti-VEGF-administered mice.

Note: Literature (Lit.) values are listed for comparison. Nude mice (n = 5) were naïve or administered a single, intravenous bolus dose (10 mg/kg) of the cross-species anti-VEGF antibody [12], B20-4.1, 24 h prior to assay. All values are reported in µL/g. Values of V_v were measured using both direct and indirect RBC labeling methods [2]. Note that the assay method can greatly influence measured V_v, especially in probe clearance organs.

^a [39].

^b [5].

^c [3].

^dMeasured using ³H-inulin.

^eFor well-perfused organs 10% vascular space is assumed [5].

^fEstimated from experimental IgG data at early time points [5].

^gEstimated from human data.

^hData reproduced with permissions [2].