. 2011 Mar 15;6(3):e17874. doi: 10.1371/journal.pone.0017874

Table 3. Volume velocities of regional blood flow (Q) in naïve and anti-VEGF-administered mice.

Tissue	Q, Literature	Q, Measured (Naïve)	Q, Measured (+ B20)
brain	850^a ^, ^e	12±1^d	12±1^d
spleen	909^b ^, ^f	169±105	153±71
liver	2103^b ^, ^f	158±20^*	200±35^*
kidney	4881^b ^, ^g	1172±419	1390±537
intestine	474^b ^, ^f	380±136	346±105
heart	3828^b ^, ^f	877±63	1026±236
lung	350^a ^, ^h	538±150	537±262
muscle	184^b ^, ⁱ	186±47	198±59
fat	190^c ^, ^j	120±37	142±34

Note: Literature values are listed for comparison. Nude mice (n = 5) were naïve or administered a single, intravenous bolus dose (10 mg/kg) of the cross-species anti-VEGF antibody [12], B20-4.1, 24 h prior to assay. All values are reported in µL/g/min. Note that the assay method can greatly influence measured values of Q, especially in probe clearance organs.

p<0.05 by unpaired t-test.

[3].

[5].

[40].

Reflects inability of probe to cross blood-brain barrier.

⁸⁵Sr-labeled microspheres [15].

Origin of measurement not specified in literature.

Extrapolated from inulin clearance rates in rat kidney [41].

Bronchial flow.

ⁱ

Measured experimentally by Rb uptake method.

Rat data; method not specified [40].