Table 5. Summary of gene set analysis results for all, high-risk, and low-risk neuroblastoma.
Gene Set Names | N° of genes | Overall Discovery p-values | Overall Replication p-values | High-risk Discovery p-values | High-risk Replication p-values | Low-risk Discovery p-values | Low-risk Replication p-values |
Nuclear Ubiquitin Ligase Complex | 10 | 1.084×10−09 | 6.620×10−03 | 1.275×10−09 | 3.024×10−02 | 0.469 | 0.753 |
Negative Regulation of Intracellular Transport | 10 | 5.692×10−07 | 1.160×10−02 | 6.332×10−07 | 3.610×10−02 | 0.361 | 0.184 |
Regulation of Phosphorylation | 42 | 6.020×10−07 | 4.142×10−02 | 2.940×10−02 | 0.925 | 1.678×10−06 | 0.960 |
Cytokine and Chemokine Mediate Signaling Pathway | 18 | 0.109 | 0.756 | 0.813 | 0.928 | 8.175×10−06 | 4.027×10−02 |
Bold face p-values of different gene sets at different risk groups (overall, high-risk, low-risk) indicate significant enrichment of that gene set in that risk group.