Figure 2. The Origin-Dependent Inverted-Repeat (ODIRA) model for Amplification of chromosomal segments.

(A) An overview of the release of a closed circular, self-complementary intermediate that arises from aberrant replication. (B) Details of the mechanism that leads to ligation of the leading and lagging strands at short, closely spaced, inverted repeats (IRs; labeled as a a′ and b b′). (C) Replication and reinsertion of the inverted dimeric amplicon into the genome by homologous recombination. See text for detailed explanations.