Table 2. Association between rs1229984, rs1573496, rs698, rs4767364, and drinking intensity in ever drinkers expressed as mean of ml of ethanol consumed per day.

		All			Controls			UADT Cases
		n	mean	CI 95%	n	mean	CI 95%	n	mean	CI 95%
rs1229984 (ADH1B)	CC	14,518	35.06	33.32–36.80	7,742	22.43	20.91–23.95	6,776	46.76	43.31–50.21
	CT,TT	1,323	22.85	18.73–26.98	907	15.60	12.35–18.85	416	23.97	14.68–33.25
p-trend				3×10−20			5×10−10			3×10−12
rs1573496 (ADH7)	GG	12,936	35.02	33.21–36.82	6,823	22.36	20.79–23.93	6,113	46.84	43.28–50.40
	GC, CC	2,926	30.29	27.36–33.22	1,822	19.68	17.25–22.11	1,104	38.73	32.68–44.78
p-trend				0.002			0.03			0.008
rs698 (ADH1C)	TT	5,574	32.05	29.69–34.41	3,054	20.65	18.65–22.66	2,520	42.17	37.48–46.85
	TC	6,748	32.51	30.29–34.74	3,685	21.40	19.51–23.29	3,063	42.32	37.91–46.74
	CC	2,377	36.15	32.92–39.39	1,285	20.42	17.63–23.22	1,092	51.03	44.74–57.31
p-trend				0.05			0.32			0.06
rs4767364 (ALDH2)	GG	7,232	33.78	31.66–35.90	4,114	21.40	19.57–23.22	3,118	45.02	40.81–49.23
	AG	6,297	33.91	31.68–36.14	3,302	21.44	19.48–23.40	2,995	45.00	40.65–49.34
	AA	1,527	35.84	31.91–39.77	718	25.09	21.43–28.74	809	45.98	38.88–53.09
p-trend				0.60			0.14			0.96

Adjusted mean of ml per day were derived from ANOVA.

P-trend were derived from a linear regression with log(ml of ethanol per day) as an outcome using a log-additive genetic model.

All estimates were adjusted by sex, age, study, pack-years (and case/control status when appropriate).