Table 1.
4-Substituted pyridine-3-carboxylic acids (2a-d) and 5-substituted pyridine-3-carboxylic acids (3a-j) obtained and evaluated as potential substrates in the chemoenzymatic synthesis designed to produce novel pyridinium substituted NAADP derivatives.
| Structure | Cmpd | Substituent | Base-exchange product detected |
|---|---|---|---|
 |
2a | -NH2 | no; yes for methyl ester |
| 2b | -CH3 | yes | |
| 2c | -n-C4H9 | yes | |
| 2d | -C6H5 | yes | |
 |
3a | -NH2 | yes |
| 3b | -CH3 | yes | |
| 3c | -Br | no | |
| 3d | -CO2H | yes | |
| 3e | -C≡CH | no | |
| 3f | -CH=CH2 | no | |
| 3g | -CH2CH3 | yes | |
| 3h | -C6H5 | no | |
| 3i | -N3 | yes | |
| 3j |  |
no | |