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. 2011 Mar 17;6(3):e17877. doi: 10.1371/journal.pone.0017877

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Kujjo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) The immobility observed in this test is considered to reflect a state of despair. CON, S1P+DXR, and bax-KO+DXR females floated less (i.e. remain less time immobile) compared to the DXR group, possibly indicating lower levels of despair in those females. While A&B illustrate the average time females remained floating, C depicts the percentage of females in the treated groups that remained floating longer than the control. (C) 40% of the females in the DXR group were above the maximum immobility time of the CON (i.e. more females in this group remain immobile and for longer periods); in the S1P+DXR group, only 16% of the females were over the maximum times in the control average. (D) Mice that perform more assessments and spend more time assessing the risk of moving out of the familiar environment are considered more anxious. Only the S1P+DXR group executed fewer risk assessments compared to the other two groups, indicating low level of anxiety. *P<0.05; **P<0.001; the number of mice analyzed per group is provided in parentheses above each bar.