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. 2011 Mar 17;6(3):e17715. doi: 10.1371/journal.pone.0017715

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Damrauer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Significantly enriched TFBS were determined by promoter analysis of genes that were affected by A20 within the following networks: cell cycle, energy production, inflammation and immune system related, and lipid and carbohydrate metabolism. The number of genes impacted by a given transcription factor are reflected by the node size and statistical enrichment (P value), using a color scale (red for highest enrichment and blue for no enrichment). P values were derived from Fisher Exact test. The TFBS analysis was performed using ExPlain 3.0 (http://explain.biobase-international.com/) for detection of over-represented transcription factor binding sites. The analysis was performed on 2000 bp upstream to 100 bp downstream of the transcription start site of each gene.