Table 4.
Odds ratio (OR) and 95% confidence interval (95% CI) of low serum uric acid (SUA) for SLC22A12 W258X among Japanese health checkup examinees
| SUA < 3 mg/dL | SUA < 4 mg/dL | |||||||
|---|---|---|---|---|---|---|---|---|
| Genotype | < 3 mg/dL | 3 mg/dL ≤ | OR | 95% CI | < 4 mg/dL | 4 mg/dL ≤ | OR | 95% CI |
| Males | ||||||||
| WW | 4 | 3,252 | 1 | Reference | 55 | 3,201 | 1 | Reference |
| WX or XX | 17 | 140 | 102.5 | 33.9-309.8 | 79 | 78 | 58.2 | 38.6-87.9 |
| Total | 21 | 3,392 | 157 | 3,279 | ||||
| Females | ||||||||
| WW | 53 | 1,484 | 1 | Reference | 436 | 1,101 | 1 | Reference |
| WX or XX | 31 | 42 | 25.6 | 14.4-45.3 | 58 | 15 | 11.9 | 6.6-21.5 |
| Total | 84 | 1,526 | 494 | 1,116 | ||||
| Both sexes | ||||||||
| Males with WW | 4 | 3,252 | 1 | Reference | 55 | 3,201 | 1 | Reference |
| Males with WX or XX | 17 | 140 | 106.5 | 35.3-321.6 | 79 | 78 | 63.7 | 42.0-96.5 |
| Females with WW | 53 | 1,484 | 27.2 | 9.8-75.4 | 436 | 1,101 | 22.4 | 16.8-29.9 |
| Females with WX or XX | 31 | 42 | 672.6 | 225.4-2006.8 | 58 | 15 | 246.3 | 130.9-363.7 |
| Interaction* | 0.23 | 0.07-0.80 | 0.17 | 0.08-0.35 | ||||
| Total | 105 | 4,918 | 628 | 4,395 | ||||
* Interaction between females and X allele for low SUA.