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Seven LHR orthologs interact with HP1 and HP6. A) LHR from seven Drosophila species interacts with D. melanogaster HP1 in a yeast two-hybrid assay. Interactions were detected by activation of HIS3 and growth on media lacking histidine (CM-trp-leu-his); growth controls (CM-trp-leu) contain histidine. The same seven LHR orthologs also interact with (B) D. melanogaster HP6 and (C) D. simulans HP6.
