Fig. 2.
Viral-mediated GABAAR δ-subunit knockdown in NAc shell decreases oral alcohol intake. Rats were infused with Ad-shδ (n = 12) to reduce expression of the δ-subunit or the control Ad-NSS (n = 12) into the NAc shell, and drinking within an intermittent-access procedure was assessed. Time course of ethanol intake expressed as grams per kilogram of body weight before (B) and after (days 5–30) virus infusion. (In Figs. 2–4, “B” refers to baseline, which is defined as the average of the last 3 d before virus infusion). *P < 0.02,**P < 0.01, and ***P < 0.005 compared with Ad-NSS. Values depict mean ± SEM.