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Inflammation in Ltbp3−/−;Ltbp4S−/− lungs. A. Macrophage infiltration in Ltbp3−/−; Ltbp4S−/− lungs. Clusters of large, activated macrophages were observed in air sacs of Ltbp3−/−;Ltbp4S−/− mice (arrows). The activated macrophages were positive for metallo-protease MMP-12 and for a macrophage-specific Mac-3 (arrows). B. Large lymphocyte infiltrations (arrows) were observed by H&E staining in some Ltbp3−/−;Ltbp4S−/− animals at P10-P21. Bars: A −20 μm, B − 40 μm.
