Table 2.

Analysis of the association between ERCC1 rs11615C>T and ERCC2 rs13181T>G polymorphisms and objective response, PFS and OS

	Objective response				PFS				OS
	Studya	Fixed effect	Random effect		Study	Fixed effect	Random effect		Study	Fixed effect	Random effect
	(Cases)	T/T+T/C vs. C/C	T/T+T/C vs. C/C	Phetb	(Cases)	T/T+T/C vs. C/C	T/T+T/C vs. C/C	Phetb	(Cases)	T/T+T/C vs. C/C	T/T+T/C vs. C/C	Phetb
ERCC1 rs11615C>T
All	9 (855)	0.81 (0.58–1.12)	0.89 (0.50–1.57)	0.005	11 (1230)	1.33 (1.15–1.54)	1.33 (0.94–1.87)	<0.001	9 (968)	1.53 (1.27–1.85)	1.51 (1.02–2.24)	<0.001
Asian	4 (378)	0.53 (0.35–0.81)	0.55 (0.31–0.98)	0.158	5 (504)	1.79 (1.45–2.21)	1.69 (1.05–2.70)	<0.001	5 (504)	2.03 (1.60–2.59)	1.95 (1.37–2.78)	0.078
Caucasian	5 (477)	1.47 (0.89–2.43)	1.44 (0.68–3.02)	0.103	6 (726)	1.00 (0.81–1.23)	1.07 (0.72–1.59)	0.004	4 (464)	0.97 (0.72–1.32)	1.10 (0.60–2.03)	0.012
Colorectal only	7 (707)	0.77 (0.54–1.12)	0.88 (0.42–1.87)	0.002	8 (993)	1.38 (1.17–1.64)	1.39 (0.89–2.17)	<0.001	6 (731)	1.58 (1.27–1.98)	1.55 (0.87–2.77)	<0.001
ERCC2 rs13181T>G		G/G+G/T vs. T/T	G/G+G/T vs. T/T			G/G+G/T vs. T/T	G/G+G/T vs. T/T			G/G+G/T vs. T/T	G/G+G/T vs. T/T
All	6 (625)	0.53 (0.37–0.78)	0.53 (0.36–0.78)	0.588	8 (931)	1.37 (1.15–1.63)	1.41 (1.06–1.89)	0.010	6 (669)	1.61 (1.29–2.00)	1.54 (0.96–2.50)	<0.001
Asian	2 (261)				2 (261)				2 (261)
Caucasian	4 (364)	0.56 (0.35–0.88)	0.56 (0.35–0.89)	0.368	6 (670)	1.33 (1.09–1.62)	1.41 (1.02–1.95)	0.022	4 (408)	1.42 (1.11–1.81)	1.42 (1.06–1.90)	0.236
Colorectal only	5 (552)	0.52 (0.35–0.77)	0.52 (0.35–0.77)	0.472	7 (858)	1.42 (1.19–1.71)	1.50 (1.11–2.02)	0.008	5 (596)	1.70 (1.36–2.13)	1.77 (1.11–2.84)	0.002

^aStudy: the number of studies included in the analysis.

^bPhet: P-value of between-study heterogeneity