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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: J Am Chem Soc. 2011 Feb 28;133(11):4018–4029. doi: 10.1021/ja109679q

Figure 1.

Figure 1

(a,b) D23N-Aβ1-40 fibril formation monitored by ThT fluorescence in unseeded experiments (i.e., generation 0) under experimental growth conditions A (□, pH 7.4, 37° C), B (○, pH 8.9, 37° C), C (Δ, pH 7.4, 37° C, agitated), and D (∇, pH 7.4, 24° C). (c-f) Negatively stained TEM images of the mature fibrils. Arrows with different styles in (c) and (f) indicate different morphologies.