Table 3. Pooled analysis for the associations between the polymorphism of TNF-α-308G>A and the risk of inflammatory bowel disease and colorectal cancer.
| Data | Test of association | Test of heterogeneity | Test of publication (P-value) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Disease | Comparison | Ethnicity | NO. | OR (95% CI) | P-value (Z test) | χ2 | I2 (%) | P-value | Rank correlation | Linear regression |
| Ulcerative colitis | GA vs GG | Europeans | 10 | 1.157 (0.769–1.742)a | 0.485 | 38.150 | 76.409 | 0.000 | 0.211 | 0.487 |
| Asians | 4 | 2.360 (1.269–4.390)a | 0.007 | 8.035 | 62.663 | 0.045 | 0.734 | 0.338 | ||
| Total | 14 | 1.420 (0.986–2.045)a | 0.060 | 57.437 | 77.366 | 0.000 | 0.063 | 0.158 | ||
| AA vs GG | Europeans | 8 | 1.836 (1.160–2.904) | 0.017 | 7.539 | 7.151 | 0.375 | 1.000 | 0.715 | |
| Asians | 4 | 2.142 (0.517–8.884) | 0.294 | 1.115 | 0.000 | 0.773 | 0.734 | 0.281 | ||
| Total | 14 | 1.862 (1.204–2.882) | 0.005 | 8.696 | 0.000 | 0.650 | 0.945 | 0.957 | ||
| GA+AA vs GG | Europeans | 10 | 1.213 (0.808–1.821)a | 0.351 | 40.559 | 77.810 | 0.000 | 0.371 | 0.597 | |
| Asians | 4 | 2.427 (1.260–4.677)a | 0.008 | 9.195 | 67.373 | 0.027 | 0.734 | 0.318 | ||
| Total | 14 | 1.474 (1.028–2.112)a | 0.035 | 59.478 | 78.143 | 0.000 | 0.080 | 0.205 | ||
| Crohn's disease | GA vs GG | Europeans | 14 | 0.975 (0.772–1.231)a | 0.832 | 31.324 | 58.498 | 0.003 | 0.155 | 0.295 |
| Asians | 4 | 0.872 (0.596–1.275) | 0.479 | 2.052 | 0.000 | 0.562 | 0.308 | 0.244 | ||
| Total | 18 | 1.003 (0.881–1.142) | 0.967 | 33.967 | 49.952 | 0.008 | 0.705 | 0.485 | ||
| AA vs GG | Europeans | 14 | 1.693 (1.151–2.492)b | 0.008 | 13.709 | 12.467 | 0.320 | 0.024 | 0.005 | |
| Asians | 4 | 1.574 (0.448–5.521) | 0.479 | 0.606 | 0.000 | 0.738 | 1.000 | 0.745 | ||
| Total | 18 | 1.683 (1.163–2.434)b | 0.006 | 14.328 | 0.000 | 0.501 | 0.043 | 0.005 | ||
| GA+AA vs GG | Europeans | 14 | 0.985 (0.773–1.254)a | 0.901 | 35.759 | 63.646 | 0.001 | 0.063 | 0.158 | |
| Asians | 4 | 0.910 (0.631–1.315) | 0.617 | 1.580 | 0.000 | 0.664 | 0.308 | 0.093 | ||
| Total | 18 | 0.992 (0.806–1.221)a | 0.942 | 37.942 | 55.195 | 0.003 | 0.495 | 0.308 | ||
| Colorectal cancer | GA vs GG | Europeans | 6 | 0.920 (0.576–1.467)a | 0.328 | 26.486 | 81.122 | 0.000 | 0.009 | 0.007 |
| Asians | 1 | 1.518 (0.365–6.320) | 0.566 | — | — | — | — | — | ||
| Total | 7 | 1.241 (0.838–1.838)a | 0.281 | 26.714 | 77.540 | 0.000 | 0.036 | 0.157 | ||
| AA vs GG | Europeans | 6 | 1.064 (0.458–2.472)a,b | 0.231 | 13.786 | 63.731 | 0.017 | 0.260 | 0.286 | |
| Asians | 1 | — | — | — | — | — | — | — | ||
| Total | 6 | 1.064 (0.458–2.472)a,b | 0.231 | 13.786 | 63.731 | 0.017 | 0.260 | 0.286 | ||
| GA+AA vs GG | Europeans | 6 | 1.298 (0.834–2.020)a,b | 0.247 | 33.274 | 84.973 | 0.000 | 0.009 | 0.007 | |
| Asians | 1 | 1.518 (0.365–6.320) | 0.566 | — | — | — | — | — | ||
| Total | 7 | 0.940 (0.592–1.492)a,b | 0.210 | 33.461 | 82.069 | 0.000 | 0.036 | 0.171 | ||
Abbreviations: OR, Odds Ratio; CI, Confidence Interval.
a
Random effect model.
b
Trim and fill.