Table 4. Association results between genome-wide CNV burden and asthma risk in 270 asthma cases and 489 controls.
| Deletions | Duplications | |||||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | P-valuea | Cases | Controls | P-valuea | |||
| Uncorrected | Corrected | Uncorrected | Corrected | |||||
| N CNVs detected | 564 | 1057 | — | — | 326 | 734 | — | — |
| N CNVs/individual | 2.09 | 2.16 | 0.8305 | 0.9989 | 1.21 | 1.50 | 0.0658 | 0.2352 |
| Total CNV span (kb) | 693.5 | 695.2 | 0.9371 | 1.0000 | 476.7 | 572.2 | 0.0282 | 0.0994 |
| Average CNV span (kb) | 223.3 | 237.3 | 0.4115 | 0.8181 | 259.1 | 269.1 | 0.5835 | 0.9623 |
| N genes spanned by CNVs | 6.67 | 7.31 | 0.4318 | 0.8165 | 4.49 | 4.01 | 0.0675 | 0.2180 |
a
Two-sided P-value estimated from 10 000 permutations. Corrected P-values were obtained after adjusting for the overall number of hypotheses tested (N=8) through the analysis of the permuted data sets.