Table 2. Meta-analysis of association with SLE for the Swedish and US cohorts.
| Swedena | USb | Meta-analysisc | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Pd | OR (95% CI) | Pd | OR (95% CI)e | Risk allele | P | Corrected Pf | OR (95% CI)e |
| IKBKE | rs1539243 | 0.031 | 1.19 (1.02–1.39) | 0.0028 | 1.20 (1.07–1.35) | C | 0.00026 | 0.0054 | 1.19 (1.09–1.31) |
| IKBKE | rs17433930 | 0.013 | 1.33 (1.06–1.67) | 0.0021 | 1.33 (1.11–1.58) | A | 0.00010 | 0.0022 | 1.33 (1.16–1.53) |
| TANK | rs3754974 | 0.0087 | 1.44 (1.09–1.89) | 0.98 | 0.99 (0.80–1.22) | NA | 0.22 | 1.0 | 1.13 (0.96–1.34) |
| TANK | rs1267075 | 0.75 | 1.02 (0.88–1.19) | 0.87 | 0.99 (0.89–1.11) | NA | 0.99 | 1.0 | 1.00 (0.92–1.10) |
| STAT1 | rs2030171 | 1.2E−05 | 1.31 (1.16–1.49) | 0.018 | 1.11 (1.02–1.21) | A | 3.3E−05 | 0.00069 | 1.17 (1.09–1.26) |
| STAT1 | rs16833172 | 0.015 | 1.51 (1.09–2.09) | 0.16 | 1.23 (0.95–1.59) | A | 0.016 | 0.34 | 1.33 (1.09–1.63) |
| IL8 | rs4694178 | 5.2E−05 | 1.26 (1.12–1.42) | 0.064 | 1.13 (1.04–1.23) | C | 0.00040 | 0.0084 | 1.17 (1.10–1.26) |
| NRP1 | rs734187 | 0.67 | 1.03 (0.90–1.18) | 0.66 | 1.01 (0.92–1.12) | A | 0.56 | 1.0 | 1.02 (0.94–1.10) |
| NRP1 | rs1331314 | 0.32 | 1.11 (0.92–1.34) | 0.11 | 1.11 (0.97–1.26) | G | 0.061 | 1.0 | 1.11 (1.00–1.23) |
| NRP1 | rs2073320 | 0.42 | 1.05 (0.93–1.18) | 0.61 | 0.98 (0.90–1.06) | NA | 0.94 | 1.0 | 1.00 (0.94–1.07) |
| TRAF6 | rs5030482 | 0.0094 | 1.25 (1.05–1.49) | 0.12 | 1.10 (0.97–1.24) | T | 0.0097 | 0.20 | 1.14 (1.03–1.26) |
| TRAF6 | rs5030472 | 0.013 | 1.28 (1.05–1.55) | 0.19 | 1.09 (0.96–1.25) | C | 0.020 | 0.42 | 1.15 (1.03–1.28) |
| STAT5B | rs6503691 | 0.44 | 1.08 (0.88–1.32) | 0.78 | 0.98 (0.86–1.12) | NA | 0.91 | 1.0 | 1.01 (0.90–1.13) |
| PIAS4 | rs2289863 | 0.19 | 1.09 (0.96–1.25) | 0.72 | 0.98 (0.89–1.08) | NA | 0.76 | 1.0 | 1.02 (0.95–1.10) |
Abbreviations: CI, confidence Interval; MAF, minor Allele Frequency; NA, not Available; OR, odds ratio; SNP, single-nucleotide polymorphism.
826 Swedish cases and 1835 controls genotyped in the discovery and replication phases including controls genotyped on the 1M chip.
1310 US SLE cases and 7859 controls genotyped in a GWAS. Genotypes for rs17433930, rs3754974, rs2030171, rs16833172, rs4694178, rs734187, rs1331314 and rs5030482 were imputed in this dataset as described in Gateva et al.
Meta-analysis including 2136 SLE cases and 9694 controls.
P-values calculated using SNPtest.
Odds ratios are calculated relative to the risk allele defined in the analysis of the combined Swedish cohort.
P-value corrected for the 21 tested SNPs.
P-values <0.05 are indicated in bold.