Figure 3.

(A) Photographs of probands 1, 3 and 4 with deletions between LCR3 and LCR4. Proband 1 (a) at 13 years of age; she has upward-slanting palpebral fissures, hypotelorism and low-set ears. Proband 3 (b) at 3 years and 7 months of age; he has dolichocephaly, low-set and prominent ears, hypertelorism, epicanthal folds and a flat midface. Proband 4 (c) at 12 years of age; he has hypertelorism, almond-shaped eyes, low-set ears and full lips. (B) Photographs of patients 9, 10 and 11 with duplications of 10q22.3q23.2. Patient 9 (d) at 9 years of age; he has a triangular face, a broad forehead, upslanting palpebral fissures, slightly deep-set eyes, lateral flaring of eyebrows, prominent ears with thickened horizontal superior helices, a thin upper lip and a smooth philtrum. Sibling patients 10 (e) and 11 (f) show upslanting palpebral fissures, strabismus, hypotelorism, a smooth philtrum and anteverted nares.