Table 4. Clinical features of probands with small sized 10q22.3q23.3 duplications with breakpoints in unique sequences.

	Patient 13	Patient 14
Duplication position (Mb)	84.5–84.8	84.2–85
LCR involvement	No	No
Inheritance	Inherited pat	Inherited pat
Additional aberrations	−	Inh 6q25.1 dup
Developmental delay	−	−
Speech delay	+ (Blindness related)	−
Seizures	−	−
Birth weight	P50	<P3
Current height	P10	P75
Current weight	P3	>P97
Deep-set eyes	+	−
Full lower lip	+	−
Strabismus	+	−
Anteverted nares	+	−
Full cheeks	+	−
Urogenital anomalies	−	+
Cardiac defect	−	+
Fusion of sacral vertebrae	−	+
Long slender ribs and clavicles	−	+

Abbreviation: LCR, low-copy repeat.

On the basis of phenotype and inheritance pattern, these aberrations most likely represent non-pathogenic variants.