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Schematic model of autophagy. Pre-autophagosomal structures form within the cytoplasm. Atg5, Atg12 and Atg16l proteins are recruited to the structure and facilitate elongation. The elongated membranes enwrap a region of the cytoplasm and its contents in a double-membraned autophagosome. Lysosomes ultimately fuse with autophagosomes releasing lysosomal hydrolases into the vesicle resulting in the degradation of its contents.
