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. 2010 Dec 20;589(Pt 4):863–875. doi: 10.1113/jphysiol.2010.200808

Figure 2. NAC specifically inhibits VEGF secretion induced by RA with VEGF transcriptional activators.

Figure 2

In A, HESC were treated overnight with the compounds as indicated in the absence or presence of the antioxidant NAC (2.5 mm). Concentrations of RA, TPA and TGF-β were as shown in the legend to Fig. 1. Results show that NAC blocked secretion of VEGF by more than 60% when combination treatment involved either TPA or TGF-β. B shows that NAC inhibited RA + TPA stimulation of VEGF but not secretion of IL-6. *Significant decrease from similarly treated cultures without NAC. Con, control.