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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Cancer Cell. 2011 Feb 15;19(2):257–272. doi: 10.1016/j.ccr.2011.01.020

Figure 1. BM-derived αSMA-expressing cells contribute to the tumor microenvironment.

Figure 1

(A) αSMA staining (upper panel) and endogenous αSMA-RFP (middle panel) or endogeneous collgen-α1 (lower panel) expression in stomachs of αSMA-RFP/collagen-α1-GFP double transgenic mice and following 12- or 18-month of H. felis infection.

(B) Relative number of αSMA (red) or collagen (green) expressing cells in the stomach of αSMA-RFP/collagen-α1-GFP double transgenic mice without and with 12- or 18 months of H. felis infection, (*=p<0,05 compared to WT and #=p<0,05 compared to 12 month)

(C) Western blot for αSMA and β-tubulin in gastric tissue of WT, IL-1β transgenic mice, and WT mice with 18 month of H. felis infection

(D) αSMA staining in a dysplastic region in 12-month old IL-1β transgenic mice and 95% co-localization of endogenous RFP expression and αSMA in stomachs of 12 months old IL-1β/αSMA-RFP mice

(E) FACS analysis of RFP+ gastric MF at 8 PD, isolated from uninfected αSMA-RFP mice (WT MF) or H. felis (18 mo) infected αSMA-RFP mice (18 months H. felis).

All data are represented as mean +/− SEM (See also Figure S1)