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C21, but not F21, irreversibly inactivates PRMT1. For these experiments, 125 µM F21 or C21 were incubated with PRMT1 for 1 h to allow for enzyme inactivation. After this incubation, the enzyme inhibitor complex, as well as controls incubated in the absence of inhibitor, were dialyzed for 24 h. Residual activity measurements were made prior to and after dialysis.
