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IC50 values for PRMT and PAD inhibitors and inactivators
| Compound | IC50 for PRMT1 (µM) |
IC50 for PRMT3 (µM) |
IC50 for PRMT4 (µM) |
IC50 for PRMT6 (µM) |
IC50 for PAD4 (µM) |
|---|---|---|---|---|---|
| C21 | 1.8 ± 0.1 | > 500 | > 500 | 8.8 ± 0.5 | 145 ± 20 |
| Cl-amidine | 225 ± 10 | > 500 | > 500 | > 500 | 5.9 ± 0.3 |
| F21 | 94 ± 17 | 109 ± 28 | > 500 | > 250 | 117 ± 14 |
| F-amidine | > 500 | > 500 | > 500 | > 500 | 21.6 ± 2.1 |
